Heidelberg is connected directly (or via Mannheim, 10 minutes) to the ICE- and IC/EC-Network of German Railways (DB). Arrival is at Heidelberg Hauptbahnhof (Central Station).
As the German Cancer Research Center is located only about 1.5 km from the Central Station, one may even walk (15-20 minutes). Upon exiting central station, head north and cross the „Kurfürsten-Anlage“ (large 4-lane-street). Walk north along the „Mittermaierstrasse“ crossing the Neckar River. Right after the bridge, make a left into „Jahnstrasse“. Follow that street until you reach the gate on the left. Pass the gate and walk into „Kirschnerstrasse“. About 100 meters down the road you will see the DKFZ main entrance to your right.
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Approaching Heidelberg on Autobahn A5 from Frankfurt or Karlsruhe, change to Autobahn A656 from direction Mannheim at the junction "Heidelberger Kreuz". Continue on Autobahn A 656 to Heidelberg, which ends at the Heidelberg City limits.
As you enter the city of Heidelberg, follow the signs „Eberbach/HD-Wieblingen/Chirurgie“: Turn left at first traffic light, then right at second. Follow the curve at the next light. Underpass the Neckar Bridge, then turn right twice heading for "Chirurgie/DKFZ". Having crossed the Neckar River, take the left lane at the first intersection and head for "Chirurgie/DKFZ". Follow this street to the next intersection. Do NOT turn left and drive through the gate, as indicated by DKFZ-signs (it's a checkpoint)! Drive straight ahead instead. To the right there are (charged) parking lots where you can park your car. From the car park walk back to the gate and pass it. Follow the street for about 100 meters. The German Cancer Research Center is the tall building on the right (for your orientation, you can find the house numbers on the top of each building; DKFZ has 280). Go straight ahead along the building, until you can see the main entrance on the right. In the entrance hall please contact the information desk for further help.
To reach the buildings in the Technologiepark (Im Neuenheimer Feld 580 and 581), follow the Berliner Str. after having crossed the Neckar River. Reaching the tramway stop "Technologiepark", turn left into the street "Im Neuenheimer Feld" (following the signs "Technologiepark").Turn right at the next intersection, after a few meters you will see the Technologiepark to the right.
Some parking lots are in front of the building Im Neuenheimer Feld 506 (turn left after passing Im Neuenheimer Feld 504).